Del Potro defeated No 31 seed Philipp Kohlschreiber of Germany 3-6, 6-3, 6-4 and Raonic beat 18th-seeded American Sam Querrey 7-5, 2-6, 6-3.
Daria Kasatkina upset Venus Williams 4-6, 6-4, 7-5 in a nearly three-hour baseline struggle and Naomi Osaka routed top-ranked Simona Halep 6-3, 6-0 in 64 minutes.
It has been a troubled season so far for the former world number one, who has not won a match since the Australian Open. Sharapova lost in the opening rounds at Doha and Indian Wells.
Roger Federer stormed his way into his 11th semi-final at the BNP Paribas Open with a dominant win over Hyeon Chung. The 36-year-old defeated his Korean opponent 7-5 6-1
The former GB No 2’s year-long suspension ends on April 23, and Lawn Tennis Association bosses have already held talks with him about his return to the game and how they might help.
The 20-year-old Japanese wasted no time in racing to a straight sets victory at Indian Wells, winning the quarter-final 6-3, 6-3 after an hour and 20 minutes. She started well and ended the match better.
The No 1 seed beat the Frenchman 7-5, 6-4, the closeness of the scoreline flattering Chardy as Federer dominated on serve and was clinical with break points. He faces Hyeon Chung in last eight.
Venus Williams defeated Anastasija Sevastova of Latvia 7-6 (8/6), 6-4 to reach the quarter-finals of the BNP Paribas Open on Tuesday as the oldest woman in the draw.
Serena Williams admits she has ‘a long way to go’ to get back to her peak after being knocked out of the BNP Paribas Open by sister Venus.
Venus Williams defeated younger sister Serena 6-3, 6-4 in the third round of the BNP Paribas Open on Monday night, her first win in the sibling rivalry since the Rogers Cup semi-final victory in 2014.